Exosomes vs Polynucleotides — What’s the Difference?

Two of the most exciting developments in regenerative aesthetics are polynucleotides and exosomes.Both treatments stimulate the skin’s natural repair and renewal processes — but they work in very different ways.

At Laser & Skin Belfast, we use only safe, products that deliver visible improvements in skin tone, texture, and firmness. Here’s how these two innovations compare.

What Are Polynucleotides?

Polynucleotides (PNs) are purified DNA fragments, usually sourced from salmon or trout.They are non-allergenic and biocompatible, meaning their molecular structure is almost identical to human DNA — but they do not alter or replace it.

Instead, they work by creating a hydrated, anti-inflammatory environment within the skin that encourages natural repair.

How They Work:

• Deeply hydrate by binding and holding water

• Reduce inflammation and oxidative stress

• Stimulate fibroblast activity to rebuild collagen and elastin

• Gradually improve skin quality and firmness

Best For:

• Dull, dehydrated, or tired-looking skin

• Loss of elasticity or early sagging

• Sensitive or post-procedure skin

Examples: Plinest, Plenhyage XL, Plenage Strong, Newest

What Are Exosomes?

Exosomes are tiny extracellular vesicles (microscopic messenger bubbles) that help cells communicate and coordinate repair. They can be derived from marine, bovine, or plant sources and are carefully purified for topical or injectable use in professional aesthetic treatments.

These exosomes contain growth factors, peptides, and antioxidant molecules that support cell health and regeneration.

How They Work:

• Deliver signalling molecules that promote healing and collagen synthesis

• Help balance pigmentation and calm inflammation

• Improve overall texture, tone, and radiance

• Boost recovery after laser or microneedling treatments

Best For:

• Ageing or photo-damaged skin

• Uneven tone and texture

• Post-treatment recovery

  
  

Where Do Skin Boosters Fit In?

Skin boosters such as Profhilo, Jalupro, Seventy Hyal, and Sunekos sit in a separate category. They are based on hyaluronic acid (HA) and amino acids — designed to improve hydration and elasticity, rather than stimulating DNA repair or intercellular communication.

They’re excellent for hydration and glow, but unlike polynucleotides and exosomes, they don’t influence deeper biological repair pathways.

The Key Differences

Feature	Polynucleotides	Exosomes	Skin Boosters
Origin	Purified DNA fragments from salmon or trout	Derived from bovine, marine (fish), or plant sources	Hyaluronic acid ± amino acids
Main Action	Creates a hydrated, anti-inflammatory healing environment	Delivers bioactive molecules that enhance skin communication	Deep hydration and elasticity boost
Mechanism	Stimulates fibroblast repair and collagen remodelling	Supports cellular signalling and antioxidant defence	Hydrates via HA water-binding effect
Primary Benefits	Firmer, calmer, healthier skin	Brighter, smoother, more even complexion	Dewy glow and moisture balance
Treatment Type	Injectable (e.g. SkinPen mesotherapy)	Topical or injected post-laser/microneedling	Injectable micro-booster
Ideal For	Sensitive, ageing, or post-procedure skin	Pigmentation, dullness, advanced ageing	Dehydrated or lacklustre skin

Can They Be Combined?

Yes — and often with fantastic synergy. Polynucleotides prepare and strengthen the skin, while exosomes enhance cellular communication and repair. Combined, they deliver a balanced, powerful improvement in tone, texture, and overall skin vitality.

The Laser & Skin Belfast Difference

Every client begins with a free skin consultation, allowing our practitioners to design a bespoke regenerative plan using only safe, clinically supported biostimulators. Whether you’re suited to polynucleotides, exosomes, or a combination, we focus on natural results, proven science, and exceptional care.

Laser & Skin Belfast — Northern Ireland’s home of next-generation regenerative skincare. Book your free consultation today and discover what’s right for your skin.

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