Understanding Biostimulators: The Future of Regenerative Aesthetics

At Laser & Skin Belfast, we specialise in treatments that help your skin rebuild itself naturally. One of the most talked-about categories in aesthetics right now is the biostimulator — injectables designed to trigger your own collagen and elastin production for firmer, smoother, more resilient skin.

But not all biostimulators are created equal. Some stimulate healthy regeneration; others rely on inflammation and fibrosis. Below, we break down the key differences — and explain why we only use the safest, most advanced options such as Polynucleotides and Profhilo Structura.

What Are Biostimulators?

Biostimulators don’t “fill” like traditional dermal fillers. Instead, they stimulate your body’s natural repair mechanisms, prompting fibroblasts to produce new collagen and elastin. The result is gradual, natural rejuvenation — improved tone, texture and firmness over time rather than instant volume.

Comparing the Main Biostimulators

Product	Main Ingredient	Reversible	Mechanism	Risk of Nodules / Complications	Inflammatory Response	Placement Sensitivity	Overall Safety
Polynucleotides (Plinest / PhilArt / Nucleofill)	Natural purified DNA fragments	✅ Naturally degrades	Cellular repair + fibroblast activation	Very low	Anti-inflammatory	Low	⭐⭐⭐⭐⭐
Profhilo Structura	Hybrid stabilised hyaluronic acid	✅ Yes – reversible	Deep dermal bio-remodelling + collagen stimulation	Very low	Minimal	Low–moderate	⭐⭐⭐⭐⭐
Hyaluronic Acid Fillers	Hyaluronic acid	✅ Yes – dissolvable	Immediate lift + hydration	Low	Minimal	Moderate	⭐⭐⭐⭐⭐
Ellansé	Polycaprolactone microspheres	❌ No	Collagen stimulation	Moderate	Low–moderate	High	⭐⭐
Radiesse	Calcium hydroxylapatite microspheres	❌ No	Fibroblast collagen stimulation	Moderate	Mild	High – must be deep	⭐⭐
Sculptra	Poly-L-lactic acid	❌ No	Inflammatory collagen stimulation	High – nodules, fibrosis	Inflammatory	High	⭐

The Regenerative Class — Polynucleotides & Profhilo Structura

These two represent the new generation of safe, bio-compatible biostimulators.

Polynucleotides

Derived from purified DNA fragments, they signal skin cells to repair and regenerate without inflammation. They improve elasticity, hydration and dermal density, making them ideal for crepey or tired skin.

Profhilo Structura

IBSA Derma’s newest launch, Profhilo Structura, works in the deep subcutaneous layer to rebuild structure and firmness. Using hybrid hyaluronic acid with unique NAHYCO® technology, it:

• Rehydrates deep tissue

• Stimulates fibroblasts, keratinocytes and adipocytes

• Restores lift and mid-face support without adding bulk. It’s the perfect bridge between a skin booster and a filler — providing gentle, reversible structural improvement.

  
  

The Older, Higher-Risk Biostimulators

Sculptra

Triggers collagen by deliberately inflaming the tissue with synthetic poly-L-lactic acid. Results can look firm or fibrotic, and nodules are a known complication. Because it’s non-reversible and unpredictable, it no longer aligns with modern safety standards.

Radiesse & Ellansé

Both are particle-based stimulators that create collagen through mechanical irritation rather than cellular healing. They can give lift, but they’re non-reversible and highly technique-sensitive, meaning even small placement errors can lead to visible irregularities or hardening.

Our Philosophy at Laser & Skin Belfast

We choose bioregenerative injectables that are:

• Reversible or naturally biodegradable

• Clinically validated for safety and predictability

• Regenerative rather than inflammatory

• Designed for subtle, natural improvement in texture, firmness and glow

That’s why our clinic offers Polynucleotides, Profhilo Structura, and premium hyaluronic-acid fillers — and not older products like Sculptra, Radiesse or Ellansé.

The Takeaway

True skin rejuvenation doesn’t rely on inflammation — it’s about regeneration. Polynucleotides and Profhilo Structura restore youthful firmness by enhancing cellular function and collagen quality, all while remaining reversible and biocompatible. They represent the safest, most advanced form of biostimulation available today.

Experience the Future of Skin Regeneration

Discover regenerative injectables that lift, tighten and rejuvenate naturally — without risk or over-filling.

👉 Book your consultation at laserandskinbelfast.co.uk

Laser & Skin Belfast

Boutique aesthetics. Medical expertise. Visible results.